BAG1 and cancer: Takahashi et al (2003) reported that transient Bag-1 knockdown in HeLa cervical carcinoma cells inhibited cell growth, and in their study this led to resistance to anti-cancer drugs, whereas others have shown that stable knockdown of Bag-1 in HeLa cells sensitised the cells to cytotoxic drug-induced apoptosis (Xiong et al 2003).