BAG1 and tongue squamous cell carcinoma: Shindoh et al (2000) reported that small primary oral tumours (T1 and T2) that had associated lymph node metastases tended to show strong Bag-1 staining. Indeed, Xie et al (2004) suggested that strong Bag-1 staining may be an indicator of poor prognosis for tongue SCC, a particularly aggressive subset of oral cancer.