In a multivariate analysis using the binary logistic regression model, high Treg significantly correlated with basal-like phenotype (OR 3.14, 95% CI 1.08 to 9.17, P = 0.004) and CXCL12 expression (OR 1.89, 95% CI 1.22 to 2.94, P = 0.004), but not tumour grade (OR 1.43, 95% CI 0.88 to 2.32, P = 0.151, Table 3). This evidence concerns the gene CXCL12 and neoplasm.