In addition to the identification of rare variants in WNK1 and WNK4 responsible for the Gordon syndrome, common single nucleotide polymorphisms (SNPs) in these genes have been associated with blood pressure variation and susceptibility to hypertension in general population among adults as well as children [Kokubo et al., 2004; Newhouse et al., 2005, 2009; Osada et al., 2009; Tobin et al., 2005, 2008]. The gene discussed is WNK4; the disease is hypertensive disorder.