hAPP: human amyloid precursor protein; AD: Azheimer's disease; s-IBM: sporadic inclusion body myositis; Aβ: β amyloid peptide; UAS: upstream activating sequence; LacZ: β-galactosidase; Dmef: Drosophila myocyte enhancer factor; GF: Giant Fiber; DLFM: dorsal longitudinal flight muscle; TTMn: tergotrochanteral motorneuron; TTM: tergotrochanteral muscle; SR: sarcoplasmic reticulum; ROS: reactive oxygen species. The gene discussed is APP; the disease is Alzheimer disease.