In the current investigation, we (1) use the Pkd1-/- model to explore the transcriptional changes that occur in ADPKD on a whole genome scale, (2) undertake a comparative transcriptomics approach to determine similarities and differences with human ADPKD, and (3) investigate whether these changes might be related to changes in miRNA expression. The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.