TGFB1 and autosomal dominant polycystic kidney disease: The comparison between our data set (differentially expressed genes at E17.5) with human ADPKD data [29] showed a 50% overlap between significantly enriched pathways (Table 4, Additional file 16), which included several important pathways such as calcium signaling, Wnt, MAPK, TGFβ signaling pathways, immune/inflammatory responses, and Notch signaling pathways.