Since knockdown of c-Myc suppressed the TRAIL-induced cleavage of DNA-PKcs and knockdown of DNA-PKcs increased TRAIL-induced activation of caspases, c-Myc overexpressed in the metastatic cancers may increase TRAIL-induced cleavage of DNA-PKcs and consequently caspase-mediated apoptosis. The gene discussed is MYC; the disease is metastatic malignant neoplasm.