In our experiment, we demonstrated that siRNA-mediated depletion of c-Myc in metastatic cancer cells suppressed TRAIL-induced up-regulation of DR5 and activation of caspase, and these phenomena could be associated with decreased cytotoxic effect of TRAIL on PC3-MM2 and KM12L4A cells. Here, TNFSF10 is linked to metastatic malignant neoplasm.