However, patients with low level MMP-11 protein had an higher median survival time and 1-year survival rate than those with high levels (11 vs. 8 months, 50.2% vs. 21.7%, P = 0.017, Figure 3) in a multivariate analysis that considered MMP-11 level as an independent factor of OS in advanced gastric carcinoma (HR = 2.618, 95%CI 1.288-5.320, P = 0.018, Table 3). This evidence concerns the gene MMP11 and gastric carcinoma.