However, a more frequent use of benzodiazepines was reported particularly in PPS+ patients (for GAD+MDD+ patients: 47.0% vs. 34.1%, p = 0.0111, PPS+ vs. PPS- respectively; for GAD+MDD- patients: 41.0% vs. 26.6%, p = 0.0023, PPS+ vs. PPS-, respectively). The gene discussed is GAD1; the disease is major depressive disorder.