TP53 and acute lymphoblastic leukemia: Given that the fate of cells exposed to DNA damage depends on the balance between the NF-κB-induced prosurvival signal and the p53-activated proapoptotic program [4], we wished to investigate whether NF-κB, in addition to p53, plays a role in the ability of cAMP to diminish the apoptotic response of BCP-ALL cells to DNA damage.