CTCs play a crucial role in tumor dissemination in relation to several biological processes, including epithelial to mesenchymal transition (EMT,) the process whereby epithelial cells lose cell-to-cell adhesion mediated by down-regulation of epithelial associated E-cadherin, and up-regulation of mesenchymal N-cadherin, allowing them to invade the extracellular matrix and migrate to a distant site [7]. Here, CDH2 is linked to neoplasm.