In fact, it has been shown that chronically increased systemic levels of IL-6 induce significant bone loss in growing IL-6 transgenic mice(23) and that chronically elevated IL-6 is associated with bone loss in postmenopausal and juvenile osteoporosis.(42,43) This cytokine also has been implicated in the pathogenesis of osteolysis associated with Paget disease,(44) multiple myeloma,(45,46) Gorham-Stout disease,(47) and juvenile idiopathic arthritis.(48). This evidence concerns the gene IL6 and primary osteolysis.