In contrast, in latently infected primary fibroblasts, MHC class I, ICAM-1, NK-cell activatory ligands and IFN-γR1 may have been downregulated during early infection, and normalisation of expression of these molecules may occur under conditions of low KSHV viral copy number and low levels of KSHV gene expression or possibly through the upregulatory effect on MHC class I expression by KSHV v-FLIP 39. The gene discussed is ICAM1; the disease is infection.