CALCA and non-small cell lung carcinoma: As shown in Figure 1, the overall methylation level of each of 6 genes was higher in NSCLC tissues than in non-cancerous lung tissues, particularly CALCA (P < 0.01), CDH1 (P < 0.01), EVX2 (P < 0.01), PAX6 (P < 0.001), and RASSF1A (P < 0.05).