From the available data, it results that antithrombin deficiency, protein C deficiency and protein S deficiency have a recurrence risk of 40% at 5 years and of 55% at 10 years comparative to 11% at 5 years and 25% at 10 years for factor V Leiden, Prothrombin G20210A and high factor 8. Here, F2 is linked to hereditary thrombophilia due to congenital protein S deficiency.