In this study, we observed that the triple-negative, Basal-like IBC cell line SUM149, a widely used model for IBC (Ignatoski and Ethier, 1999; Hoffmeyer et al, 2005; Dong et al, 2007; Streicher et al, 2007; Aird et al, 2010; Wu et al, 2010; Singh et al, 2010a, 2010b), and rSUM149, an IBC cell line with acquired resistance to ErbB1/2 targeted agents (Aird et al, 2010), had significantly higher GLI1 expression than other cell lines tested and that targeting GLI1 by siRNA reduced cell proliferation and migration and increased apoptosis. The gene discussed is EGFR; the disease is inflammatory breast carcinoma.