As GLI1 has been observed to promote cell migration and invasion in other cancer cell types (Das et al, 2009; Lo et al, 2009), including non-IBC breast cancer cell lines (Kameda et al, 2009; Souzaki et al, 2011), we were interested to determine if it has a role in the invasive potential of SUM149 and rSUM149 cells. This evidence concerns the gene GLI1 and breast cancer.