GLI1 and inflammatory breast carcinoma: In this study, we observed that the triple-negative, Basal-like IBC cell line SUM149, a widely used model for IBC (Ignatoski and Ethier, 1999; Hoffmeyer et al, 2005; Dong et al, 2007; Streicher et al, 2007; Aird et al, 2010; Wu et al, 2010; Singh et al, 2010a, 2010b), and rSUM149, an IBC cell line with acquired resistance to ErbB1/2 targeted agents (Aird et al, 2010), had significantly higher GLI1 expression than other cell lines tested and that targeting GLI1 by siRNA reduced cell proliferation and migration and increased apoptosis.