The cellular models that were used for this study are the only well-established IBC cellular models available; SUM149, an ErbB1 activated, triple-negative (ErbB2-, ER- and PR-) cell line and SUM190, an ErbB2 overexpressed, ER- cell line, both of which have been derived from primary IBC tumours (Forozan et al, 1999). The gene discussed is ERBB2; the disease is inflammatory breast carcinoma.