The only previous reports connecting the Hh-Gli pathway with IBC was a gene array study linking a three-gene signature including the Sonic hedgehog (SHH) gene with poor outcome in IBC patients (Bieche et al, 2004), and another gene expression study demonstrating that IBC is characterised by Hh-pathway hyperactivation (Van Laere et al, 2010). Here, GLI1 is linked to inflammatory breast carcinoma.