It has been showed that Nlp is frequently overexpressed in extensive epithelial malignant tumours, for instance, 80% breast cancer tissues, 65.8% of head and neck squamous cell carcinoma (HNSCC) and 78% of lung cancer (Qu et al, 2008; Yu et al, 2009). The gene discussed is NINL; the disease is head and neck squamous cell carcinoma.