The fact that NDPK-B activates its vascular endothelial receptor (P2Y receptor), which in turn activates VEGFR-2 in the absence of VEGF (Figures 2 and 8) offers the intriguing possibility that focusing on P2Y mechanisms in angiogenesis might broaden the armamentarium in prevention of breast cancer metastasis. Here, NME2 is linked to breast cancer.