The fact that NDPK-B activates its vascular endothelial receptor (P2Y receptor), which in turn activates VEGFR-2 in the absence of VEGF (Figures 2 and 8) offers the intriguing possibility that focusing on P2Y mechanisms in angiogenesis might broaden the armamentarium in prevention of breast cancer metastasis. This evidence concerns the gene VEGFA and breast cancer.