For example, in non-small cell lung cancer (NSCLC) phosphorylation of Akt on Ser473 has in some studies been found to correlate with poor prognosis (David et al, 2004; Tang et al, 2006; Lim et al, 2007), whereas others have found that it has no prognostic significance (Mukohara et al, 2003; Tsao et al, 2003; Massion et al, 2004). This evidence concerns the gene AKT1 and non-small cell lung carcinoma.