Taken together with our own data, showing PRAS40 to strongly correlate with Akt Thr308 phosphorylation, suggests that Akt Thr308 and/or PRAS40 Thr246 phosphorylation would be good candidate biomarkers to assess Akt activity in NSCLC. This evidence concerns the gene AKT1S1 and non-small cell lung carcinoma.