The Akt pathway represents one of the most frequently dysregulated pathways found in human cancer (Altomare and Testa, 2005; Cheng et al, 2005) and is a critical mediator of the survival and proliferative effects of several oncogenes including mutant forms of the EGF receptor, Ras and PI3-kinase, as well as the Bcr-Abl fusion protein (Yuan and Cantley, 2008). The gene discussed is AKT1; the disease is cancer.