For domain HNF-1B_C (PF04812), we notice that Urhammer et al. [60] have pointed out that mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3), and for domain HNF-1_N (PF04814), mutations and the common polymorphism Ala/Val in position 98 of HNF-1 also cause MODY3. The gene discussed is NEFH; the disease is type 2 diabetes mellitus.