Furthermore, the fact that the most successful mAbs, clinically accepted for cancer therapy, are directed against sensitive surface receptors (EGFR and HER2) or calcium pump like structure (CD20), suggests that at least part of the anti-tumour effect of mAbs is induced by their capacity to activate or block a pathway of internal signalling, leading to inhibition of tumour cell proliferation. Here, EGFR is linked to cancer.