To further examine the role of induced tetherin in replication-competent HIV-1 infection and transmission mediated by DCs, we assessed the effect of tetherin knockdown on the release of WT and Vpu-deleted (ΔVpu) HIV-1 from infected mature DCs and on DC-mediated HIV-1 transmission to Hut/CCR5 cells. The gene discussed is SGTA; the disease is HIV-1 infection.