Using KEGG database [25] we analyzed signaling pathways with significant hits (P < 0.0001) for predicted targets involved in endocytosis (hsa04144), pathways in cancer (hsa05200), mTOR signaling pathway (hsa04150), hedgehog signaling pathway (hsa04340), chronic myeloid leukemia (hsa05220), focal adhesion (hsa04510) and Wnt signaling (hsa04310) (Table 3). The gene discussed is MTOR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.