As shown in our real-time qPCR data (Figure 3), the rather decreased levels of miR-181a, miR-221 and miR-19a in some imatinib treated patients, and miR-103 down-regulation in a number of blast crisis, diagnosis and progressed CML may contribute to the increased level of PI3K and thus may be involved in the previously described PI3K/AKT/mTOR signaling activation and in the resistance development in some CML cases. Here, MTOR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.