In addition, multiple differentially expressed MYC/MYCN target genes in stage 4+ tumor appear to be associated with splicing processing complex, such as small nuclear ribonucleoprotein polypeptides (SNRPA, SNRPB, SNRPD2), dead-box polypeptides (DDX1, DDX18), RNA-binding motif protein (RBM3), and cleavage and polyadenylation specific factor (CPSF1) [29,33]. Here, DDX18 is linked to neoplasm.