Considering the following possible sequence of events previously suggested [13], high sympathetic tonus associated with hyperglycemia leads to overexpression of GLUT2, increased glucose reabsorption, higher interstitial concentrations of glucose, more glucose available to mesangial cells, GLUT1 overexpression [12], higher glucose uptake by mesangial cells and, finally, acceleration of the well-known intracellular steps involved in the pathogenesis of diabetic nephropathy. The gene discussed is SLC2A1; the disease is Hyperglycemia.