The aim of the present study was to determine whether the IVS3+nt460A/G, +nt437C/T and exon E197G A/G T2D risk (SNPs) of PSMD9 cause evidence for linkage with other T2D-associated phenotypes such as CAD, stroke/TIA, vasculopathy and macrovascular pathology of T2D in Italians. This evidence concerns the gene PSMD9 and stroke disorder.