TNC and idiopathic pulmonary fibrosis: In addition, Tn-C has been shown to be increased in a number of other lung diseases associated with remodelling of extracellular matrix (ECM), such as idiopathic pulmonary fibrosis (IPF), allergic alveolitis, sarcoidosis, asbestosis, cryptogenic organizing pneumonia (COP), tuberculosis, atypical mycobacteriosis, lung cancer, mesothelioma and inflammatory myofibroblastic tumor [18-20], Tn-C has also been reported to be expressed, during fetal development of the human lung [21] but not in healthy human adult lung.