Nor was any association between MBL-high genotype and RA observed when the association estimate was adjusted for three established risk factors for RA (smoking, SE, and PTPN22*620W) in the multivariate model (adjusted OR 0.99, 95% CI 0.83 to 1.18), but as expected, these risk factors were significantly associated with RA (ever smoking: adjusted OR 1.39, 95% CI 1.17 to 1.67; SE: adjusted OR 2.76, 95% CI 2.32 to 3.28; and PTPN22*620W: adjusted OR 1.47, 95% CI 1.21 to 1.79). This evidence concerns the gene PTPN22 and rheumatoid arthritis.