We have shown that UHRF1 represses the expression of tumour suppressor genes such as p16INK4A &RB1 leading to a down-regulation of the Vascular Endothelial Growth Factor (VEGF, Figure 2A) [49] and by a feedback mechanism, UHRF1 may be regulated by other tumour suppressor genes such as p53 and p73 products [46,67]. This evidence concerns the gene VEGFA and neoplasm.