In the present study, we analyzed the effects of bergamot extracts and their putative isolated compounds on the production of IL-8 in cystic fibrosis IB3-1 and CuFi-1 cells [27,40-42] induced to hyper secretion of pro-inflammatory chemokines following treatment with TNF-α [17,43,44] or exposure to heat-inactivated Pseudomonas aeruginosa. The gene discussed is CXCL8; the disease is cystic fibrosis.