IL1B and cystic fibrosis: Massive infiltration of neutrophils in airways, enhanced adherence of neutrophils to CF airway epithelial cells [11,12], elevated levels of cytokines and chemokines in bronchoalveolar lavage fluids such as IL-1β and IL-8 [13,14], may contribute to an over exuberant pro-inflammatory response in lungs of patients with CF.