Interestingly, the degradation of apoptotic cells utilizes many genes that also function in receptor-mediated endocytosis, and their mutation can result in various human diseases (e.g., mammalian orthologues of RAB-5 in tuberous sclerosis, Dynamin-2 and Rab7 in Charcot-Marie-Tooth disease [35]–[37]). This evidence concerns the gene RAB5A and tuberous sclerosis.