Of the genes shared by two datasets, four were components of the angiogenesis pathway, including EPHA3 and FRS2. We noted also that several members of the WNT (WNT3A, 4, 5B, 7A, 9A, 11, 16) or cadherin (CDH2, 4, 9, 12, 17, 18, 19) gene families were affected by SCNA in only one dataset, further reinforcing the idea that different genes can potentially alter the same pathway (WNT or cadherin) in different melanoma samples. The gene discussed is FRS2; the disease is melanoma.