Exogenous expression of ADAMTS-1 has been shown to decrease the experimental metastasis of Chinese hamster ovary cells [46] but increase the metastatic potential of mammary and lung cancer cell lines in vivo[47] whereas our study demonstrates that increased expression levels of ADAMTS-1 do not alter the invasive capacity of human trophoblastic cells in vitro. This evidence concerns the gene ADAMTS1 and lung cancer.