In lieu of novel data describing ADAMTS-12 as a putative tumor suppressor gene expressed predominantly in the stroma [49], [50], further studies are required to evaluate the biological and clinical significance of (dys)regulated expression levels of ADAMTS-12 in the onset and/or progression of cancer to the later stages of the disease state, and to delineate the function of this ADAMTS subtype in processes such as cell migration, invasion, and growth in other in vivo tumor model systems. The gene discussed is ADAMTS12; the disease is neoplasm.