Consistent with this concept, Tip60 HAT activity has been implicated in the age-related neurodegenerative disorder Alzheimer's disease (AD) via its HAT dependent complex formation with the C-terminal fragment of the amyloid precursor protein (AICD-APP) and linker protein Fe65 [73], [74], [75]. This evidence concerns the gene TMPRSS11D and early-onset autosomal dominant Alzheimer disease.