The mRNA and/or protein levels of ST2, soluble ST2, which acts as a decoy receptor for IL-33, and IL-33 are increased in specimens from patients with allergic diseases such as asthma [26], [27], [28], [29], [30], [31], conjunctivitis [31], rhinitis [24] and atopic dermatitis [32]. The gene discussed is IL1RL1; the disease is allergic disease.