Another suggestion that downregulation of VEGF signalling within the glomerulus may be involved in the renal lesion of preeclampsia is given by S. Quaggin's group: they described the development of preeclampsia-like endotheliosis and “bloodless glomeruli” in mice with podocyte-specific heterozygosity for VEGF. The gene discussed is VEGFA; the disease is preeclampsia.