VEGF ablation therapy by bevacizumab (a humanized monoclonal antibody that recognizes and blocks vascular endothelial growth factor A (VEGF-A)), sorafenib (a small molecular inhibitor of several tyrosine kinases), sunitinib (an oral, small-molecule, multitargeted receptor tyrosine kinase (RTK) inhibitor) and other anti-VEGF drugs are frequently complicated by mild proteinuria and hypertension. The gene discussed is VEGFA; the disease is hypertensive disorder.