The inactivation of the tumor suppressor DPC4 (deleted in pancreatic carcinoma, locus 4), also called SMAD4 or MADH4 is most frequently found in ductal pancreatic adenocarcinomas (approx. 50%) and metastatic colon carcinomas (approx. 30%) [1,2]. This evidence concerns the gene SMAD4 and exocrine pancreatic carcinoma.