We first demonstrated that genetic variants rs3761847 and rs7021206 in TRAF1/C5 locus are significantly associated with RA in the Han Chinese, suggesting that TRAF1/C5 may play a role in the development RA in this population, which expands the pathogenesis role of TRAF1/C5 in a different ethnicity. This evidence concerns the gene C5 and rheumatoid arthritis.