In a multivariable model including age, gender, history of hypertension, time since diagnosis of type 2 diabetes, BMI, HbA1c, the presence of albuminuria, and loge (NT-proBNP), the significant determinants of LVH were: BMI (χ2 24.7; <0.001), age (χ2 8.3; p = 0.004), history of hypertension (χ2 4.9; p = 0.028), and gender (χ2 4.1; p = 0.043). The gene discussed is NPPB; the disease is type 2 diabetes mellitus.