ICs could be endocytosed by the natural IFNα producing cells, the plasmacytoid dendritic cells (pDCs) and induce IFNα production through Toll-like receptor (TLR) 7 or TLR9 stimulation [21,22], which is considered to have a key role in the pathogenesis of SLE [23]. The gene discussed is IFNA1; the disease is systemic lupus erythematosus.