Konigshoff and colleagues [48], [50] confirmed the up-regulation of WNT1, WNT7B and WNT10B, FZD2, FZD3, β-catenin, and LEF1 expression in the lungs of individuals with idiopathic pulmonary fibrosis compared to transplant donor lung. This evidence concerns the gene FZD3 and pulmonary fibrosis.