Since pkd2 is specifically known to beimportant for cilia function, and our in vitro analysisrevealed ADPKD-like behaviour in Sec10 knockdown cells, we wanted to determinewhether Sec10 knockdown would share phenotypes associated withpkd2 knockdown in vivo as well.Importantly, we noticed that the curly tail up phenotype of sec10MO embryos wasreminiscent of the unique curly tail up observed from loss ofpkd2 in zebrafish (uninjected: 0% curly tail up,n = 42; compared to 15ng sec10MO: 51%,n = 97; and 8+8ng sec10MO: 6%,n = 32; Figure4A and 4C) [20], [29]-[31]. The gene discussed is EXOC5; the disease is autosomal dominant polycystic kidney disease.