EXOC5 and autosomal dominant polycystic kidney disease: We demonstrate that Sec10 knockdown also leads to phenotypes associated with ADPKD.In vitro, we show that knockdown of Sec10 leads to decreasedbasal intracellular calcium levels and lack of a calcium response to fluid flow.Conversely, Sec10-overexpressing cells showed a significantly increased calciumresponse to fluid flow.