To determine whether the effect of BMS is specific to MCF-7 cells and whether other IKKβ inhibitors have a similar effect as BMS, we extended the studies to two additional human lung cancer cell lines H1299 and H1648 and two other potent IKKβ inhibitors SC-514 [13] and TPCA-1 [14] and observed similar results as seen in MCF-7 cells treated with BMS (Figure 2). The gene discussed is IKBKB; the disease is lung cancer.