In contrast, in the abnormal human brain nestin-expression in neurons has been reported in various pathological states such as in the dentate gyrus of pediatric patients with temporal lobe epilepsy [27], in adult patients with cortical dysplasia and partial seizures [28], and in Purkinje cells of the cerebellum and in neurons in the frontal and temporal lobes of patients with Creutzfeldt-Jakob disease [29]–[31]. Here, NES is linked to Creutzfeldt Jacob disease.