Magnesium (Mg) is an important cofactor for the enzymes that are involved in carbohydrate metabolism: an important role of Mg in insulin action has been reported [1, 2]; low serum and intracellular Mg ([Mg2+]i) concentrations are associated with insulin resistance, impaired glucose tolerance, and decreased insulin secretion [3, 4]. Here, INS is linked to Impaired glucose tolerance.