Overall, breadths of CD8+IFNγ+, CD8+Perforin+ and CD8+IFNγ+Perforin+ at STI/CT randomization lacked correlation with the nadir CD4+ count and did not differ in subjects that took ART for either 52 or 76 weeks before STI/CT randomization (Figure 2). This evidence concerns the gene CD4 and sexually transmitted disease.