We have speculated that elevated plasma Hb-bound VWF, parallely with increased ECHb, might play an important role in the culmination of blood cell (including platelets, sickle RBCs, and neutrophils) adhesion to vascular endothelium and development of related crises events such as thrombosis, thromboembolism, ischemic strokes, and myocardial infarctions in patients with SCA. Here, VWF is linked to autosomal dominant cerebellar ataxia.