Indeed, the Rere protein is able to directly bind the other atrophin paralog ATN1, which is responsible for the neurodegenerative disorder dentatorubral-pallidoluysian atrophy (DRPLA) [40], and to induce its massive re-localization in the nucleus upon overexpression [41]. Here, ATN1 is linked to Dentatorubral pallidoluysian atrophy.