The most studied genes related to the onset of HNSCC are epidermal growth factor receptor (EGFR), Cyclin D1, p53, and Human Papilloma Virus (HPV), while the expression of matrix metallopeptidases (MMP) and vascular endothelial growth factor (VEGF) are associated with the metastatic phenotype (for review see references [5,6]). Here, EGFR is linked to head and neck squamous cell carcinoma.