SQSTM1 and pancreatic adenocarcinoma: It is possible that the high expression of Nrf2 in the pancreatic adenocarcinoma tissues is due to the elevated expression of proteins that can increase the stability of Nrf2, such as Sequestosome-1 [33,34] and Prothymosin-α [35], by competing with Nrf2 for the Keap1 binding site.