KEAP1 and familial pancreatic carcinoma: We next explored the function of the Nrf2/Keap1 system in three pancreatic cancer cell lines showing extremes of Nrf2/Keap1 expression; Suit-2 (lowest Keap1 and highest Nrf2), FAMPAC (highest Keap1 and lowest Nrf2), and MiaPaca-2 (high Keap1 with a lack of correlation between levels of Nrf2 and expression of Nrf2 target genes) (Figure 1).