KEAP1 and familial pancreatic carcinoma: There was no correlation between the presence of Keap1 and the levels of either cytosolic or nuclear Nrf2 in the pancreatic tumors (P = 0.47 and P = 0.86, respectively, Mann-Whitney U-test), indicating that the dysregulated Nrf2/Keap1 phenotype observed in some pancreatic cancer cell lines is also apparent in primary tumors.