NFE2L2 and familial pancreatic carcinoma: In order to further define the role of Nrf2 in determining the proliferation rate of pancreatic cancer cells, propidium iodide staining was employed to examine the cell cycle status of Suit-2 and FAMPAC (i.e. cells that exhibit high and low basal levels of Nrf2 activity, respectively) following siRNA depletion of Nrf2.