Figure 7C shows that GBM-M stem cells spheres express transcription factors such as HIF-1α and NF-kB as well as the pro-inflammatory proteins RAGE, P2X7R, COX2 and PTX3, and the chemokine (C-X-C motif) receptor 4 (CXCR4). The gene discussed is CXCR4; the disease is glioblastoma.